ANASTROZOLE MSDS PDF

Anastrozole ≥98% (HPLC); CAS Number: ; Synonym: 2;2. SAFETY DATA SHEET. SECTION 1: PRODUCT IDENTIFICATION. ANASTROZOLE, USP. PRODUCT NAME. PRODUCT CODE. MEDISCA Inc. Material Safety Data Sheet of Anastrozole contains identification of substance and details of the supplier of the safety data sheet.

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Anastrozole is a drug indicated in the treatment of breast cancer in post-menopausal women. It is used both in adjuvant therapy i. It decreases the amount of estrogens that the body makes. Anastrozole belongs in the class of drugs known as aromatase inhibitors. It inhibits the enzyme aromatase, which is responsible for converting androgens produced by women in the adrenal glands to estrogens. For adjuvant treatment of hormone receptor positive breast canceras well as hormonal treatment of advanced breast cancer in post-menopausal women.

Anastrozol also been used to treat pubertal gynecomastia and McCune-Albright syndrome; however, manufacturer states that efficacy for these indications have not been established. Anastrozole is a potent and selective non-steroidal aromatase inhibitor indicated for the treatment of anastrozolf breast cancer in post-menopausal women with disease progression following tamoxifen therapy.

Many breast cancers have estrogen receptors and growth of these tumors can be stimulated by estrogens. In post-menopausal women, the principal source of circulating estrogen primarily estradiol is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues, such as adipose tissue, with further conversion of estrone to estradiol.

Many breast cancers also contain aromatase; the importance of anasfrozole estrogens is uncertain. Treatment of breast cancer has included efforts to decrease estrogen msda by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor anashrozole or delayed progression of tumor growth in some women.

Anastrozole is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone. Anastrozole selectively inhibits aromatase. The principal source of circulating estrogen primarily estradiol is conversion of adrenally-generated androstenedione to estrone by aromatase in peripheral tissues.

Therefore, aromatase inhibition leads to anasrtozole decrease in serum and tumor concentration of estrogen, leading to a decreased tumor mass or delayed progression of tumor growth in some women. Anastrozole has no detectable effect on synthesis of adrenal corticosteroids, aldosterone, and thyroid hormone. Rapidly absorbed into the systemic cirulation following oral administration. Peak plasma concentrations are usually attained within 2 hours under fasting conditions, anastrozols steady-state plasma concentrations attained in approximately 7 anastrizole.

Metabolized mainly by N-dealkylation, hydroxylation, and glucuronidation to inactive metabolites. Primary metabolite is an inactive triazole. Patent US, issued August 24, Drug created on June 13, Anastrozole Targets 1 Enzymes 4 Biointeractions 5.

Drug Interaction R -warfarin The metabolism of R -warfarin can be decreased when combined with Anastrozole. Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Anastrozole. Abiraterone The metabolism of Abiraterone can be decreased when combined with Wnastrozole.

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Anastrozole – DrugBank

Aceclofenac The metabolism of Aceclofenac can be decreased when combined with Anastrozole. Acefylline The metabolism of Acefylline can be decreased when combined with Anastrozole. Acenocoumarol The metabolism of Acenocoumarol can be decreased when combined with Anastrozole. Acetaminophen The metabolism of Acetaminophen can be decreased when combined with Anastrozole. Acetohexamide The anasttozole of Acetohexamide can be decreased when combined with Anastrozole. Acetyldigitoxin Acetyldigitoxin may decrease the cardiotoxic activities of Anastrozole.

Acetyldigoxin Acetyldigoxin may decrease the cardiotoxic activities of Anastrozole. Acetylsalicylic acid The metabolism of Acetylsalicylic acid can be decreased when combined with Anastrozole. Acyclovir The metabolism of Acyclovir can be decreased when combined with Anastrozole.

Adinazolam The metabolism of Adinazolam can be decreased when combined with Anastrozole. Agmatine The metabolism of Agmatine can be decreased when combined with Anastrozole. Agomelatine The metabolism of Agomelatine can be decreased when combined with Anastrozole.

Albendazole The metabolism of Albendazole can be decreased when combined with Anastrozole. Aldosterone The metabolism of Aldosterone can be decreased when combined with Anastrozole. Aldoxorubicin The risk or severity of cardiotoxicity can be increased when Anastrozole is combined with Aldoxorubicin. Alfentanil The metabolism of Alfentanil can be decreased when combined with Anastrozole.

Alfuzosin The metabolism of Alfuzosin can be decreased when anastrozoel with Anastrozole. Allylestrenol The metabolism of Allylestrenol can be anastrozolr when combined with Anastrozole. Almotriptan The meds of Almotriptan can mses decreased when combined with Anastrozole. Alogliptin The metabolism of Alogliptin can be decreased when combined with Anastrozole. Alosetron The metabolism of Alosetron can be decreased when combined with Anastrozole. Alprazolam The metabolism of Alprazolam can be decreased when combined with Anastrozole.

Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Anastrozole. Ambroxol The metabolism of Ambroxol can be decreased when combined with Msvs. Aminophenazone The metabolism of Aminophenazone can be decreased when combined with Anastrozole.

Aminophylline The metabolism of Aminophylline can be decreased when combined with Anastrozole.

Amiodarone The metabolism of Amiodarone can be decreased when combined with Anastrozole. Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Anastrozole. Amlodipine Msss metabolism of Amlodipine can be decreased when combined with Anastrozole.

Amprenavir The metabolism of Amprenavir can be decreased when combined with Anastrozole. Amsacrine The risk or severity of cardiotoxicity can be anastrozolf when Amsacrine is combined with Anastrozole.

Anagrelide The metabolism of Anagrelide can be decreased when combined with Anastrozole. Ancestim The risk or severity of cytotoxicity can be increased when Ancestim is combined with Anastrozole. Androstenedione The metabolism of Androstenedione can be decreased when combined with Anastrozole. Antipyrine The metabolism of Antipyrine can be decreased when combined with Anastrozole.

Apalutamide The metabolism mss Apalutamide can be decreased when combined with Anastrozole. Apixaban The metabolism of Apixaban can be decreased when combined with Anastrozole. Apremilast The metabolism of Apremilast can be decreased when combined with Anastrozole.

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Material Safety Data Sheet of Anastrozole | AbMole BioScience

Aprepitant The metabolism of Aprepitant can be decreased when combined with Anastrozole. Aranidipine The metabolism of Aranidipine can be decreased when combined with Anastrozole. Arformoterol The metabolism of Arformoterol can be decreased when combined with Anastrozole.

Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Anastrozole.

Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Anastrozole. Arsenic trioxide The risk or severity of cardiotoxicity can be increased when Arsenic trioxide is combined with Anastrozole. Artemether The metabolism of Artemether can be decreased when combined with Anastrozole. Artesunate The metabolism of Artesunate can be decreased when combined with Anastrozole. Asenapine The metabolism of Asenapine can be decreased when combined with Anastrozole.

Astemizole The metabolism of Astemizole can be decreased when combined with Anastrozole. Asunaprevir The metabolism of Asunaprevir can be decreased when combined with Anastrozole. Atazanavir The metabolism of Atazanavir can be decreased when combined with Anastrozole. Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Anastrozole.

Atovaquone The metabolism of Atovaquone can be decreased when combined with Anastrozole. Avanafil The metabolism of Avanafil can be decreased when combined with Anastrozole. Axitinib The metabolism of Axitinib can be decreased when combined with Anastrozole.

Azathioprine The metabolism of Azathioprine can be decreased when combined with Anastrozole. Azelastine The metabolism of Azelastine can be decreased when combined with Anastrozole. Azelnidipine The metabolism of Azelnidipine can be mds when combined with Anastrozole. Azithromycin The metabolism of Azithromycin can be decreased when combined with Anastrozole. Balaglitazone The metabolism of Balaglitazone can be decreased anastrozloe combined with Anastrozole. Bamifylline The metabolism of Bamifylline can be decreased when combined with Anastrozole.

Banoxantrone The metabolism of Banoxantrone can be decreased when combined with Anastrozole. Baricitinib The metabolism of Baricitinib can be decreased xnastrozole combined with Anastrozole. Barnidipine The metabolism of Barnidipine can be decreased when combined with Anastrozole.

Beclomethasone dipropionate The metabolism of Beclomethasone dipropionate can be decreased when combined with Anastrozole. Bedaquiline The metabolism of Bedaquiline can be decreased when combined with Anastrozole. Bencyclane The metabolism of Bencyclane can be decreased when combined with Anastrozold.

Anastrozole

Bendamustine The metabolism of Bendamustine can be decreased naastrozole combined with Anastrozole. Benidipine The metabolism of Benidipine can be decreased when combined with Anastrozole. Benzodiazepine The metabolism of Benzodiazepine can be decreased when combined with Anastrozole. Benzphetamine The metabolism of Benzphetamine can be decreased when combined with Anastrozole. Benzyl alcohol The metabolism of Benzyl alcohol can be decreased when combined with Anastrozole.