AMILOIDOSIS MACULAR PDF

Macular amyloidosis is a pruritic eruption that is variable in severity and consists of small, dusky-brown or grayish pigmented macules. Macular amyloidosis (MA) is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly. CASE REPORT. An unusual presentation of macular amyloidosis. Bárbara Lima Araújo MeloI; Igor Santos CostaII; Clara de Assis Martins GoesIII; Celina Aguiar.

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Macular Amyloidosis (Friction Amhyloidosis)

Typical histological findings are an amorphous amyloid deposit in the papillary dermis between the interpapillary pegs, where foci of pigmentary incontinence can frequently be found. An antigenic identity between epidermal keratin and skin amyloid. The natural course of the disease is not well described. Congo Red staining left maculaf Thioflavin-T staining with fluorescent microscopy right.

On viewing, the Congo red-stained sections under polarized light, amyloid deposits with apple green birefringence were detected in seven biopsy specimens [ Figure 4 ]. Ratz, J, Bailin, P. Etretinate for the treatment of lichen amyloidosis. New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis.

Topical calcineurin inhibitors 0. Bony prominences such as clavicular and scapular regions were involved in three patients each, with rare sites like the buttocks being involved in one patient. Systemic therapies such as retinoids, cyclophosphamide, and cyclosporine have been shown to reduce pruritus and promote clearance of lesions but have more associated side effects.

Family history is important because hereditary forms of macular amyloidosis do exist. Macular amyloidosis MA is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly over the trunk and extremities.

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You must be a registered member of Dermatology Advisor to post a comment. Please review our privacy policy. Poikiloderma-like cutaneous amyloidosis in an ethnic Chinese girl. Treatment with ultraviolet B. In our study, there was a wide variation in the duration of the disease ranging from 1 month to 12 years.

Macular form of cutaneous amyloidosis was first described by Palitz and Peck in Cutaneous amyloidosis associated with atopic disorders. Advertising revenue supports our not-for-profit mission. Kobayashi H, Hashimoto K.

Macular Amyloidosis (Friction Amhyloidosis)

What is the Cause of the Disease? Author information Article notes Copyright and License information Disclaimer. Encouraging results were reported with the use of Q-switched Amikoidosis Identification of gammaglobulins and C3 in the lesions by immunofluorescence. Epidemiologymacular amyloidosisrisk factors. YAG laser therapy for reduction of pigmentation in macular amyloidosis patches. Amiloodosis J Dermatol Venerol Leprol. We did not observe such a pattern in our study. Accessed December 31st, Nylon cloth macular amyloidosis.

Histopathological examination of the cutaneous lesion revealed significant quantities of an amyloid deposit in the papillary dermis, which could be more clearly observed after Congo red staining, as well as foci of pigmentary incontinence.

Genotype and Phenotype of Transthyretin Cardiac Amyloidosis. Accessed April 27, A year-old, dark-skinned housewife was followed up after presenting with a one-year complaint of dark, non-itching lesions on her arms, neck, lower back and legs.

Amyloid is an abnormal protein that is amiloidosks in your bone marrow and can be deposited in any tissue or organ. A recently discovered cytokine, interleukin ILhas been proposed to play a role in itching[ 49 ] and has been implicated in the pathophysiology of itchy dermatosis such as PLCA sporadic and amiloiodsis.

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No side effects were observed, and patients tolerated the pain of the laser treatment well. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra-lesional injections of anti-amyloid antibodies.

A Clinico-Epidemiological Study of Macular Amyloidosis from North India

Macular amyloidosis MA was first described in by Palitz and Peck. Amyloidosis; Congo Red; Hyperpigmentation. Amyloidosis can affect different organs in different people, and there are different types of amyloid. Complete history and physical examination to exclude any associated systemic disorder or drug usage leading to cutaneous pigmentation was obtained. This content does not have an Arabic version.

Brownstein MH, Hashimoto K. By registering you consent to the collection and use of your information to provide the products and services you have requested from us and as described in our privacy policy and terms and conditions.

Rajkumar SV, et al. Most cases can be treated with strong topical corticosteroids, normally for a short period. In the patient studied here this failed to reveal any abnormal results.